24h-Sammelurin
24-Stunden-Sammelurin
Foto: Fraunhofer IBMT
Eine ideale Matrix für das Human-Biomonitoring, weil mit dem Urin Chemikalien und/oder deren Metabolite ausgeschiedenen werden, die zuvor in direktem Kontakt mit dem Organismus standen. Messungen im Urin können somit zuverlässige Aussagen über die interne Belastung des Menschen liefern.
Die Niere ist das Hauptausscheidungsorgan für resorbierte anorganische und organische Xenobiotika. Für essentielle Bestandteile des menschlichen Körpers fungiert es als Regulationsorgan. Über die Konzentrationsbestimmungen im Urin lassen sich Expositionen gegenüber Fremdstoffen erkennen. Gleichermaßen liefert diese Matrix wertvolle Informationen über den individuellen Gesundheitszustand.
Weitergehende Informationen zur Probenart, Probenahme und Probenbearbeitung finden Sie in der Richtlinie zur Probenahme und Probenbearbeitung 24-h-Sammelurin (2015) - IBMT.
Für Untersuchungen der Jahre 2011 bis 2014 finden Sie die Vorschriften in der Richtlinie zur Probenahme und Probenbearbeitung 24-h-Sammelurin (2011) - UKM.
Datenrecherche
Probenahmegebiete
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4 Universitätsstädte als Standorte für die Probenahme.
Analyte
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Achtzig Prozent der Elemente auf der Erde gehören zu den Metallen
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Nur achtzehn Elemente im Periodensystem
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Gruppe organischer Verbindungen mit wenigstens einem kovalent gebundenen Chloratom
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Gruppe organischer Verbindungen mit mindestens drei kondensierten Sechserringen
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Weichmacher für PVC und andere Kunststoffe
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Wirtschaftlich wichtiger Ausgangsstoff für Kunststoffe wie Polycarbonate und Epoxydharze
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Chemische Stoffe gegen Schadorganismen und für Pflanzenschutz
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Gruppe nichtionischer Tenside und ihrer Abbauprodukte
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Weit verbreitete Lösungsmittel, die als reproduktionstoxisch eingestuft sind
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Konservierungsmittel in Nahrung und Kosmetika
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Schutz für Mensch und Produkte
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Duftstoffe kommen in einer Vielzahl von Produkten vor
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Zusatzinformationen für die Interpretation von Belastungsdaten
Untersuchungszeitraum
1982 - 2021
Weiterführende Informationen
Literaturangaben
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The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank
Wiesmüller, G.A.; Eckard, R; Dobler, L.; Günsel, A.; Oganowski, M.; Schröter-Kermani, C.; Schlüter, C.; Gies, A.; Kemper, F. H.
International Journal of Hygiene and Environmental Health 210 (2007), 3-4, 299-305, 2007
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Internal phthalate exposure over the last two decades – A retrospective human biomonitoring study
Wittassek, Matthias; Wiesmüller, Gerhard A.; Koch, Holger M.; Eckard, Rolf; Dobler, Lorenz; Helm, Dieter; Müller, Johannes; Angerer, Jürgen; Schlüter, Christoph
International Journal of Hygiene and Environmental Health 210 (2007), 3-4, 319-333, 2007
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Trends of the internal phthalate exposure of young adults in Germany - Follow-up of a retrospective human biomonitoring study
Göen, Thomas; Dobler, Lorenz; Koschorreck, Jan; Müller, Johannes; Wiesmüller, Gerhard A.; Drexler, Hans; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 215 (2011), 1, 36-45, 2011
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Phthalate metabolites in 24-h urine samples of the German Environmental Specimen Bank (ESB) from 1988 to 2015 and a comparison with US NHANES data from 1999 to 2012
Koch, Holger M.; Rüther, Maria; Schütze, André; Conrad, André; Pälmke, Claudia; Apel, Petra; Brüning, Thomas, Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health (2016), online 9. November 2016, 2016
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Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 hr urine samples from the German Environmental Specimen Bank
Schütze, André; Kolossa-Gehring, Marike; Apel, Petra; Brüning, Thomas; Koch, Holger M.
International Journal of Hygiene and Environmental Health (2013), online 16. August 2013, 2013
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Bis-(2-propylheptyl)phthalate (DPHP) metabolites emerging in 24 hour urine samples from the German Environmental Specimen Bank (1999 to 2012)
Schütze, André; Gries, Wolfgang; Kolossa-Gehring, Marike; Apel, Petra; Schröter-Kermani, Christa; Fiddicke, Ulrike; Leng, Gabriele; Brüning, Thomas; Koch, Holger M.
International Journal of Hygiene and Environmental Health (2015), online 1. Juni 2015, 2015
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Parabens in 24 h urine samples of the German Environmental Specimen Bank from 1995 to 2012
Moos, Rebecca K.; Koch, Holger M.; Angerer, Jürgen; Apel, Petra; Schröter-Kermani, Christa; Brüning, Thomas; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 218 (2015), 7, 666-674 , 2015
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Daily intake and hazard index of parabens based upon 24 h urine samples of the German Environmental Specimen Bank from 1995 to 2012
Moos, Rebecca K.; Apel, Petra; Schröter-Kermani, Christa; Kolossa-Gehring, Marike; Brüning, Thomas; Koch, Holger M.
Journal of Exposure Science and Environmental Epidemiology, online 30. November 2016, 2016
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Trends in characteristics of 24-h urine samples and their relevance for human biomonitoring studies – 20 years of experience in the German Environmental Specimen Bank
Lermen, Dominik; Bartel-Steinbach, Martina; Gwinner, Frederik; Conrad, André; Weber, Till; von Briesen, Hagen; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health (2019), online 26. April 2019, 2019
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Internal exposure of young German adults to di(2-propylheptyl) phthalate (DPHP): Trends in 24-h urine samples from the German Environmental Specimen Bank 1999-2017
Schmidtkunz, Christoph; Gries, Wolfgang; Weber, Till; Leng, Gabriele; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health (2019), online 14. Februar 2019, 2019
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Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014
Ulrich, Nadin; Bury, Daniel; Koch, Holger M.; Rüther, Maria; Weber, Till; Käfferlein, Heiko-Udo; Weiss, Tobias; Brüning, Thomas; Kolossa-Gehring, Marike
Int Arch Occup Environ Health (2018); online 22. August 2018, 2018
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Biomonitoring of new contaminants: Sub-Project 2 – Screening of target and non-target contaminants in human blood and urine
Plaßmann, Merle; Brack, Werner; Krauss, Martin
Leipzig: Helmholtz Zentrum für Umweltforschung - UFZ, 2016. - 122, FKZ 3710622202, 2016
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Glyphosate in German adults - Time trend (2001 to 2015) of human exposure to a widely used herbicide
Conrad, André; Schröter-Kermani, Christa; Hoppe, Hans-Wolfgang; Rüther, Maria; Pieper, Silvia; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 220 (2017), 1, 8-16; online 29. September 2016, 2016
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Discovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB)
Göen, Thomas; Lermen, Dominik; Hildebrand, Jörg; Bartel-Steinbach, Martina; Weber, Till; Kolossa-Gehring, Marike
Toxicology Letters (2018), online 12.Juni 2018, 2018
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Time trend of exposure to the phthalate plasticizer substitute DINCH in Germany from 1999 to 2017: Biomonitoring data on young adults from the Environmental Specimen Bank (ESB)
Kasper-Sonnenberg, Monika; Koch, Holger M.; Apel, Petra; Rüther, Maria; Pälmke, Claudia; Brüning, Thomas; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health (2019), online 1. August 2019, 2019
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German Environmental Specimen Bank: 24-hour urine samples from 1999 to 2017 reveal rapid increase in exposure to the para-phthalate plasticizer di(2-ethylhexyl) terephthalate (DEHTP)
Lessmann, Frederik; Kolossa-Gehring, Marike; Apel, Petra; Rüther, Maria; Pälmke, Claudia; Harth, Volker; Brüning, Thomas; Koch, Holger Martin
Environment International 132 (2019), 105102, 2019
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N-methylmalonamic acid (NMMA) as metabolite of methylisothiazolinone and methylchloroisothiazolinone in 24-h urine samples of the German Environmental Specimen Bank from 2000 to 2017 - exposure and time trends
Schettgen, Thomas; Rüther, Maria; Weber, Till; Kraus, Thomas; Kolossa-Gehring, Marike
Chemosphere (2019), 125743; online 27. Dezember 2019, 2019
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Time course of phthalate cumulative risks to male developmental health over a 27-year period: Biomonitoring samples of the German Environmental Specimen Bank
Apel, Petra; Kortenkamp, Andreas; Koch, Holger M.; Vogel, Nina; Rüther, Maria; Kasper-Sonnenberg, Monika; Conrad, André; Brüning, Thomas; Kolossa-Gehring, Marike
Environmental International 137 (2020), 105467; online 6. Februar 2020, 2020
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Biomonitoring data on young adults from the Environmental Specimen Bank suggest a decrease in the exposure to the fragrance chemical 7-hydroxycitronellal in Germany from 2000 to 2018
Pluym, Nikola; Petreanu, Wolf; Weber, Till; Scherer, Max; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 227 (2020), Juni 2020, 113508; online 12. März 2020, 2020
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Time trend of the exposure to geraniol in 24-h urine samples derived from the German Environmental Specimen Bank from 2004 to 2018
Pluym, Nikola; Stöckelhuber, Markus; Weber, Till; Scherer, Gerhard; Scherer, Max; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 239 (2022), 113880; online 10. November 2021, 2021
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Quantification of a mercapturate metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone (“M-12”) in human urine using online-SPE-LC/MS/MS
Schettgen, Thomas; Bertram, Jens; Kraus, Thomas; Kolossa-Gehring, Marike
Analytical Methods 13 (2021), 1847-1856; online 16. März 2021, 2021
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Human biomonitoring in urine samples from the Environmental Specimen Bank reveals a decreasing trend over time in the exposure to the fragrance chemical lysmeral from 2000 to 2018
Scherer, Max; Petreanu, Wolf; Weber, Till; Scherer, Gerhard; Pluym, Nikola; Kolossa-Gehring, Marike
Chemosphere (2020), 128955; online 12. November 2020, 2020
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A biomonitoring study assessing the exposure of young German adults to butylated hydroxytoluene (BHT)
Schmidtkunz, Christoph; Küpper, Katja; Weber, Till; Leng, Gabriele; Kolossa-Gehring, Marike
International Journal of Hygiene and Environmental Health 228 (2020), Juli 2020, 113541; online 5. Mai 2020, 2020
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Long-term monitoring of mercury in young German adults: Time trend analyses from the German Environmental Specimen Bank, 1995–2018
Bartel-Steinbach, Martina; Lermen, Dominik; Gwinner, Frederik; Schäfer, Moritz; Göen, Thomas; Conrad, André; Weber, Till; von Briesen, Hagen; Kolossa-Gehring, Marike
Environmental Research 207 (2022), 112592; online 31. Dezember 2021, 2022