Total volume (urine)

Essential additional parameter for the determination and assessment of renal function

The total volume is the amount of excreted urine (in millilitres) in a given time (often within 24 h). It is an important parameter for assessing the renal function by estimating the efficiency of renal detoxification (renal clearance). Renal clearance describes the ability of the kidneys to filtrate a certain amount of a substance (mostly creatinine) out of a specific blood plasma volume in a given time. The total urine volume is needed for the calculation of the clearance:

Clearance = (Substance concentration in urine x urine volume) / (substance concentration in blood x urine sampling time)

The total volume is influenced by the dietary uptake of fluids, the fluid loss, e.g. by sweating, and the functioning of the kidneys.


Students Student groups with an even number of female and male students at the age of 20 to 29.

Sampling area

Sampling sites (humans) 4 university cities as sampling areas.

Sampling period

1986 - 2018