Important substitute for phthalates
Di(2-ethylhexyl) terephthalate (DEHTP) is used as plasticizer in polyvinylchloride (PVC) materials at 15 - 30 % mass. DEHTP is allowed to be used in food contact materials.
Common products are bottle caps, tubings, conveyor belts, sealings but also soles of shoes, cabel tubings, flooring materials and waterproof clothing.
DEHTP production is listed in the REACH registry with about 10 000 to 100 000 t per year.
DEHTP is used as phthalate alternative for the heavily regulated phthalate DEHP. It has a similar structure, terephthalates have functional groups on opposing sites compared to phthalates with functional groups next to each other, and thus similar physical properties.
The European Food Safety Authority (EFSA) evaluated DEHTP in 2008 and derived a tolerable daily intake (TDI) of 1 mg/kg bodyweight per day.
5cx-MEPTP1-mono-(2-ethyl-5-carboxyl-pentyl) benzene-1,4-dicarboxylate is a metabolite of DEHTP
5oxo-MEHTP1-mono-(2-ethyl-5-oxo-hexyl) benzene-1,4-dicarboxylate is a metabolite of DEHTP
5OH-MEHTP1-mono-(2-ethyl-5-hydroxy-hexyl) benzene-1,4-dicarboxylate is a metabolite of DEHTP
2cx-MMHTP1-mono-(2-carboxyl-methyl-hexyl) benzene-1,4-dicarboxylate is a metabolite of DEHTP
Student groups with an even number of female and male students at the age of 20 to 29.
1999 - 2017
Links to external information and legislation
German Environmental Specimen Bank: 24-hour urine samples from 1999 to 2017 reveal rapid increase in exposure to the para-phthalate plasticizer di(2-ethylhexyl) terephthalate (DEHTP)
Lessmann, Frederik; Kolossa-Gehring, Marike; Apel, Petra; Rüther, Maria; Pälmke, Claudia; Harth, Volker; Brüning, Thomas; Koch, Holger Martin
Environment International 132 (2019), 105102, 2019